Inferring Stabilizing Mutations from Protein Phylogenies: Application to Influenza Hemagglutinin
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چکیده
منابع مشابه
Inferring Stabilizing Mutations from Protein Phylogenies: Application to Influenza Hemagglutinin
One selection pressure shaping sequence evolution is the requirement that a protein fold with sufficient stability to perform its biological functions. We present a conceptual framework that explains how this requirement causes the probability that a particular amino acid mutation is fixed during evolution to depend on its effect on protein stability. We mathematically formalize this framework ...
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ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2009
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1000349